HBcrAg stands for Hepatitis B core related antigen and is a combination of
- HBeAg: information about replication status of the virus
- p22cr: empty virus particle
- HBcAg: this protein is not detectable as such in blood as it is always part of a complex
These three diferent types of antigen proteins are trans- lated by the mRNA of transcriptional products of cccDNA, which itself is generated by the HBV replication process in hepatocytes.1
Schematics of precore/core genes and their products1
Kimura T, et al. Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J Biol Chem. 2005 Jun 10;280(23): 21713-9.