Soluble mesothelin-related peptides (SMRP) – High stability of a potential tumor marker for mesothelioma.

30/03/2016
Author:  Weber D.G. et al.

Weber D.G., et al.
Cancer Biomarkers. 3(2007)287-292.

The stability of the soluble mesothelin related peptide (SMRP) was evaluated using the MESOMARK assay in a population of healthy volunteers.

The goal of this study was to look at the effect of long term storage, short term storage and multiple freeze-thaws on the level of SMRP in serum. A total of 98 samples were collected and stored at -80ºC, 30 samples from the total were aliquoted and stored at different conditions for testing of the samples for 5 days at -80ºC, at room temperature and results after 10 freeze/thaw cycles. The researchers first looked at the SMRP distribution in the normal patient population and used this to calculate the cut-off for SMRP. The researchers ran a number of statistical analyses on the data set and set their cut off at the 95th percentile of the log normal distribution, which resulted in a value of 1.5-1.6 nM. All of the evaluations for the SMRP stability gave results that were within the assay imprecision which shows that the SMRP is a very stable marker in serum. The researchers did report a small increase in the SMRP values over 5 days following multiple freeze/thaw cycles, how-ever this effect does not take place after a single cycle.

Overall the SMRP has a high level of stability in serum in multiple conditions and the use of SMRP is not limited based on sample stability.

CLOSE

You can change the country filter for contents in our website. You will then see local contact information and other information available for that country. Please choose your country in the list below:

Please log in to react

Welcome to Fujirebio

It looks as if you are visiting from the United States. The content of this website is not destined for United States visitors.

If you continue your visit you confirm that you understand that not all of the products you will see listed are FDA cleared. FDA cleared products may not be cleared for all indications mentioned on this site. Product claims may differ from country to country based on regulations and approvals.

Please contact your country representative for further details.