Biomarker: PIVKA-II (Protein Induced Vitamin K Absence or Antagonist-II)

A biomarker of liver cells for the management of hepatocellular carcinoma (HCC)

PIKVA-II is an immature form of prothrombin also known as DCP (Des-gamma-Carboxy Prothrombin), vitamin Kcoagulation factor, synthesized in the liver. In absence of vitamin K or when its action is antagonized (warfarin), PIVKA-II is released into the blood.

Phenotypic changes of liver cells enhance the production of PIVKA-II via impairments of vitamin K uptake1. PIVKA-II is an established HCC marker.

PIVKA-II serum and tissue overexpression are related to worse tumor behavior2-3, such as the presence of (micro) vascular invasion and intrahepatic metastasis of HCC cells and may indicate a poor prognostic outcome.


Lumipulse® G PIVKA-II

PIVKA-II is a biomarker of liver cells for the management of hepatocellular carcinoma (HCC). Our Lumipulse G immunoreaction cartridges are for in vitro diagnostic (IVD) use with the LUMIPULSE G system for the quantitative measurement of protein induced vitamin K absence or antagonist-II (PIVKA-II) in serum.

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