Biomarker: PIVKA-II (Protein Induced Vitamin K Absence or Antagonist-II)

A biomarker of liver cells for the management of hepatocellular carcinoma (HCC)

PIKVA-II is an immature form of prothrombin also known as DCP (Des-gamma-Carboxy Prothrombin), vitamin Kcoagulation factor, synthesized in the liver. In absence of vitamin K or when its action is antagonized (warfarin), PIVKA-II is released into the blood.

Phenotypic changes of liver cells enhance the production of PIVKA-II via impairments of vitamin K uptake1. PIVKA-II is an established HCC marker.

PIVKA-II serum and tissue overexpression are related to worse tumor behavior2-3, such as the presence of (micro) vascular invasion and intrahepatic metastasis of HCC cells and may indicate a poor prognostic outcome.

 

Lumipulse® G PIVKA-II

PIVKA-II is a biomarker of liver cells for the management of hepatocellular carcinoma (HCC). Our Lumipulse G immunoreaction cartridges are for in vitro diagnostic (IVD) use with the LUMIPULSE G system for the quantitative measurement of protein induced vitamin K absence or antagonist-II (PIVKA-II) in serum.

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We are a global leader in the field of high quality in vitro diagnostics (IVD) testing. We have more than 50 years’ accumulated experience in the conception, development, production and worldwide commercialization of robust IVD products. Our IVD product lines span the range from specialized manual and automated testing to fully automated routine clinical laboratory testing solutions.

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