Biomarkers: β-amyloid and tau

Biomarkers for Alzheimer's disease

Alzheimer’s disease (AD) is the most common form of dementia and is histologically characterized by the accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles throughout the brain.

The major constituents of amyloid plaques are the β-amyloid peptides consisting of 40 and 42 amino acids, which are derived from the amyloid precursor protein.

Neurofibrillary tangles are made up of paired helical filaments consisting of hyperphosphorylated tau protein (phospho-tau). Tau protein, present in the brain in 6 different isoforms, is an intracellular protein that is released upon neuronal death. 

The INNOTEST® assays from Fujirebio are solid-phase enzyme immunoassays for the quantitative determination of β-amyloid(1-42), β-amyloid(1-40), total Tau, and phospho-Tau(181P) in human cerebrospinal fluid. The combined use of these markers allows identification of AD pathology ante-mortem in order to discriminate AD from normal aging1, other neurological diseases and other types of dementia (non-AD). 

The availability of these markers on fully automated platforms will simplify and boost their implementation in clinical routine. In 2017, Fujirebio launched the first ever fully automated tests for Alzheimer's disease, starting with the Lumipulse® G β-amyloid 1-42 and Total Tau assays, with more assays to come.  

Not for in vitro diagnostic use in the United States. Product claims may differ from country to country on regulations and approvals. Please contact your country representative for further details.

Reference:

  1. http://www.alzforum.org/alzbiomarker

 

Download our whitepaper to learn more about the importance of CSF biomarker testing
in the diagnostic work - up of suspected Alzheimer’s disease patients.

 

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