Biomarker: KL-6 (Krebs von den Lungen-6)

An add-on marker for the diagnostic and management of Interstital Lung Diseases (ILDs)

Krebs von den Lungen 6 (KL-6) is a mucin-like, highmolecular weight glycoprotein expressed on the surface membrane of alveolar epithelial cells (AEC-II) and bronchiolar epithelial cells. It exists as solubilized component in the pulmonary epithelial lining fluid by proteolytic cleavage.

  • When these cells are proliferating, stimulated or injured, KL-6 is released into the blood vessel (damaged barrier).
  • KL-6 has chemotactic, proliferative effects on fibroblasts. It correlates with fibrogenesis.
  • KL-6 is a good marker of AEC injury. Its role in patients with Interstital Lung Diseases (ILDs) and connective tissue diseases has been extensively studied1.

References:

  1. Ishikawa et al. Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases. RESPIRATORY INVESTIGATION 2012; 50:3–13

Lumipulse® G KL-6 (Krebs von den Lungen)

KL-6 is an add-on marker for the diagnostic and management of Interstital Lung Diseases (ILDs). Our Lumipulse G immunoreaction cartridges are for in vitro diagnostic (IVD) use with the fully automated LUMIPULSE G System for the quantitative measurement of sialylated carbohydrate antigen, KL-6 in serum or plasma.

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